Y16
Synonym(s):4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
- CAS NO.：429653-73-6
- Empirical Formula: C24H20N2O3
- Molecular Weight: 384.43
- MDL number: MFCD03083787
- Update Date: 2026-08-05 19:35:02
What is Y16?
Biological Activity
Y16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.
in vitro
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.
Cell Viability Assay
| Cell Line: | NIH 3T3 cells |
| Concentration: | 10 μΜ, 30 μΜ |
| Incubation Time: | 24 hours |
| Result: | Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA. |
Western Blot Analysis
| Cell Line: | NIH 3T3 cells |
| Concentration: | 10 μΜ, 30 μΜ |
| Incubation Time: | 24 hours |
| Result: | Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA. |
Properties of Y16
| Density | 1.273±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 8.84±0.20(Predicted) |
| form | powder |
| color | , faint yellow to dark orange |
Safety information for Y16
Computed Descriptors for Y16
New Products
2-Amino-5-bromo-4-(trifluoromethyl)pyridine Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
You may like
-
Rho Inhibitor II, Y16 CAS 429653-73-6View Details
429653-73-6 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1 -
1191-95-3 Cyclobutanone 98+View Details
1191-95-3 -
213382-45-7 98+View Details
213382-45-7 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.