CTS-1027
- CAS NO.：193022-04-7
- Empirical Formula: C19H20ClNO6S
- Molecular Weight: 425.88
- MDL number: MFCD16657131
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-05 11:31:08
What is CTS-1027?
Biological Activity
CTS-1027 is a potent MMP inhibitor with IC50 values of 0.3 nM and 0.5 nM for MMP2 and MMP13, respectively.
in vivo
CTS-1027 significantly reduces the hepatocyte apoptosis, features of cholestatic liver injury, amd markers of hepatic fibrogenesis in the BDL mouse. It improves overall animal survival following 14 days of BDL in mice. In male animals treated for 8 weeks the terminal plasma concentration of RS-130830 is 311±45 nM. Treatment of male mice with RS-130830 for 8 weeks causes an 89% increase in plasma triglyceride concentration, but there is no corresponding effect in female mice treated for 12 Plaque. The lipid content of animals receiving RS-130830 is increased by 81% at 12 weeks, and increased by 41% at 16 weeks.
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Properties of CTS-1027
| Density | 1.388±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO |
| pka | 9.27±0.23(Predicted) |
| form | A solid |
| color | White to off-white |
Safety information for CTS-1027
Computed Descriptors for CTS-1027
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