Y 134
- CAS NO.：849662-80-2
- Empirical Formula: C28H28N2O3S
- Molecular Weight: 472.6
- MDL number: MFCD09970973
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is Y 134?
The Uses of Y 134
Y 134 is a SERM displaying selectivity for ERα over ERβ.
What are the applications of Application
Y 134 is a SERM displaying selectivity for ERα over ERβ
Definition
ChEBI: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(4-propan-2-yl-1-piperazinyl)phenyl]methanone is an aromatic ketone.
Biological Activity
Selective estrogen receptor modulator (SERM) that displays selectivity for ER α over ER β (K i values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.
Storage
Desiccate at RT
Properties of Y 134
| storage temp. | Desiccate at RT |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| form | Powder |
Safety information for Y 134
Computed Descriptors for Y 134
New Products
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