XLR11 N-(4-hydroxypentyl) metabolite (CRM)

Description

XLR11 is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB₂ receptor over the central CB₁ receptor.¹ XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors.² XLR11 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of XLR11, based on the known metabolism of similar compounds.^3,4 The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.

The Uses of XLR11 N-(4-hydroxypentyl) metabolite (CRM)

4-Hydroxypentyl XLR11 is a metabolite of XLR11 (X746300), an aminoalkylindole compound that is expected to be a cannabinoid (CB) mimetic.

Definition

ChEBI: XLR11 N-(4-hydroxypentyl) metabolite is a member of indoles.

References

1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).
2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives US7241799B2,(2001).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB₂) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
4. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).