XLR11 6-hydroxyindole metabolite

Description

XLR11 is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB₂ receptor over the central CB₁ receptor.¹ XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors.² XLR11 6-hydroxyindole metabolite is an expected minor monohydroxylated urinary metabolite of XLR11.³ The biological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.

References

1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).
2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives US7241799B2,(2001).
3. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).