VU0155041 sodium salt

CAS NO.：1259372-69-4
Empirical Formula: C14H14Cl2NNaO3
Molecular Weight: 338.162
Update Date: 2026-01-05 11:31:08

What is VU0155041 sodium salt?

Description

VU0155041 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with an EC₅₀ value of 2.5 μM for glutamate response in a thallium flux assay. It is selective for mGluR4, exhibiting no effect on radioligand binding at 67 G protein-coupled receptors, ion channels, and transporters, and lacking antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. In vivo, VU0155041 decreases catalepsy induced by haloperidol and reverses askinesias induced by reserpine in rat models of Parkinson’s disease. Chronic treatment with VU0155041 restores social behavior in the Oprm^-/- mouse model of autism. It also increases the percentage of time spent in the open arms of the elevated plus maze, a measure of decreased anxiety, in mice.

The Uses of VU0155041 sodium salt

VU 0155041 Sodium Salt is a positive allosteric modulator of group III mGlu4 receptor that provides functional neuprotection in 6-hydroxydopamine rat models with parkinson’s disease.

What are the applications of Application

VU 0155041 sodium salt is a potent, positive allosteric mGluR-4 modulator

Properties of VU0155041 sodium salt

storage temp.	Desiccate at RT
solubility	DMSO: 1 mg/ml; PBS (pH 7.2): 2 mg/ml
form	Powder
Water Solubility	Soluble to 25 mM in water

Safety information for VU0155041 sodium salt

Computed Descriptors for VU0155041 sodium salt

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