VU 0357017 hydrochloride
Synonym(s):4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride;CID 25010775;ML071 hydrochloride;SID 56353039
- CAS NO.：1135242-13-5
- Empirical Formula: C18H28ClN3O3
- Molecular Weight: 369.9
- MDL number: MFCD17215959
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-27 08:46:37
What is VU 0357017 hydrochloride?
The Uses of VU 0357017 hydrochloride
VU 0357017 Hydrochloride is a cholinergic M1 receptor antagonist and a cholinomimetic agent used for the treatment of behavioral and/or mental disorders.
The Uses of VU 0357017 hydrochloride
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.
What are the applications of Application
VU 0357017 hydrochloride is a positive mAChR M1 (allosteric muscarinic M1 receptor) modulator
Storage
+4°C
Properties of VU 0357017 hydrochloride
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to off-white |
Safety information for VU 0357017 hydrochloride
Computed Descriptors for VU 0357017 hydrochloride
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