VU 0357017 hydrochloride

The Uses of VU 0357017 hydrochloride

VU 0357017 Hydrochloride is a cholinergic M1 receptor antagonist and a cholinomimetic agent used for the treatment of behavioral and/or mental disorders.

The Uses of VU 0357017 hydrochloride

VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.

What are the applications of Application

VU 0357017 hydrochloride is a positive mAChR M1 (allosteric muscarinic M1 receptor) modulator

Storage

+4°C