VU 0364439
- CAS NO.：1246086-78-1
- Empirical Formula: C18H13Cl2N3O3S
- Molecular Weight: 422.29
- MDL number: MFCD22378484
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-27 08:46:37
What is VU 0364439?
The Uses of VU 0364439
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) (1,2).
What are the applications of Application
VU 0364439 is a positive allosteric modulator (PAM) of mGluR-4
References
[1]. lucyna pomierny-chamioło, kinga rup, bartosz pomierny, et al. metabotropic glutamatergic receptors and their ligands in drug addiction. pharmacology & therapeutics, 2014, 142:281-305.
[2]. albert j. robichaud, darren w. engers, craig w. lindsley, et al. recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as cns therapeutics. acs chemical neuroscience, 2011, 2:433-449.
[3]. colleen m. niswender, kari a. johnson, c. david weaver, et al. discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. mol. pharmacol., 2008, 74(5):1345-1358.
[4]. darren w. engers, patrick r. gentry, richard williams, et al. synthesis and sar of novel, 4-(phenylsulfamoyl)phenylacetamide mglu4 positive allosteric modulators (pams) identified by functional high-throughput screening (hts). bioorg. med. chem. lett., 2010, 20:5175-5178.
Properties of VU 0364439
| Density | 1.538±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥21.11 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| form | solid |
| pka | 7.71±0.10(Predicted) |
| color | White to off-white |
Safety information for VU 0364439
Computed Descriptors for VU 0364439
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