VS-5584

CAS NO.：1246560-33-7
Empirical Formula: C17H22N8O
Molecular Weight: 354.41
MDL number: MFCD25372027
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is VS-5584?

Description

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.

Properties of VS-5584

Boiling point:	687.2±65.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥17.7 mg/mL in DMSO; ≥4.71 mg/mL in EtOH with ultrasonic
form	solid
pka	4.53±0.10(Predicted)
color	Light yellow to yellow

Safety information for VS-5584

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P501:Dispose of contents/container to..…