Vantas
- CAS NO.：220810-26-4
- Empirical Formula: C66H86N18O12
- Molecular Weight: 1323.52
- MDL number: MFCD00918679
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is Vantas?
Description
Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.
Definition
ChEBI: An acetate salt obtained by combining histrelin with acetic acid. The amount of acetic acid present can vary and a variable amount of water may be present. Histrelin acetate is used as a subcutaneous hydrogel implant for the treatment of prostate cancer an for the suppression of gonadal sex hormone production in children with central precocious puberty.
Properties of Vantas
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
Safety information for Vantas
Computed Descriptors for Vantas
New Products
5-Chlorothiophene-2-carboxylic acid 2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-3-methyl xanthine Maleic hydrazide 6-Methyl-2-(p-tolyl)imidazo[1,2-a]pyridine 3,4-Dihydroxyacetophenone 3,4-Dimethoxyacetophenone 4-Nitroacetophenone DL-Glutamic acid 3-Nitroacetophenone 4'-Chloro-3'-nitroacetophenone 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 1-Boc-4-cyanopiperidine 2-Fluoro-6-iodobenzoic acid 3-Pyridineacrylic acid 3-Hydroxy-2-methylbenzoic acid 1,3-Dibromo-5-fluorobenzene 2-((2,6-Difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid [N(E)]-N-Ethylidene-2-methyl-2-propanesulfinamide 4-Isopropyl Thiophenol 6-(chloromethyl)pteridine-2,4-diamine monohydrochloride 2-Chlorophenyl diphenyl chloromethaneRelated products of tetrahydrofuran
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