COMPUTED DESCRIPTORS
| Molecular Weight | 1383.6 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 16 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 34 |
| Exact Mass | 1382.68838962 g/mol |
| Monoisotopic Mass | 1382.68838962 g/mol |
| Topological Polar Surface Area | 487 Ų |
| Heavy Atom Count | 100 |
| Formal Charge | 0 |
| Complexity | 2690 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Histrelin Acetate is the acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production.