Ipamorelin

Synonym(s):2-Methylalanyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-D-phenylalanyl-L-lysinamide acetate;Aib-His-D-2-Nal-D-Phe-Lys-NH2 acetate;NNC 26-0161 acetate;

CAS NO.：170851-70-4
Empirical Formula: C38H49N9O5
Molecular Weight: 711.85
MDL number: MFCD02179658
EINECS: 227-005-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-19 18:11:36

What is Ipamorelin?

Description

Ipamorelin (INN) (developmental code name NNC 26-0161) is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue.It is a pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 that was derived from GHRP-1.

The Uses of Ipamorelin

Ipamorelin was originally developed by Novo Nordisk, and was investigated in phase II clinical trials by Helsinn Therapeutics for the treatment of postoperative ileus, but was discontinued due to lack of efficacy.Ipamorelin has been used by athletes as a performance enhancing drug.

The Uses of Ipamorelin

Ipamorelin is a metabolite of growth hormone releasing peptides (GHRPs). Ipamorelin is a pentapeptide with strong growth hormone releasing potency that evokes insulin release from pancrease of normal and diabetic rats.

Benefits

Ipamorelin has a wide range of benefits for the human body such as: reduced body fat, increased collagen production, increased lean muscle mass, improved sleep, increased cell repair and regeneration, elevated IGF-1, increased bone mineral content, counteracted glucocorticoid catabolism, decreased appetite stimulation compared to GHRP-6, decreased release of cortisol, prolactin and aldosterone. Decreased release of cortisol, prolactin and aldosterone.

Side Effects

Ipamorelin is generally considered safe and well tolerated, with common side effects including dizziness, headache, nausea, diarrhoea and flushing. Allergic or serious adverse reactions are rare.

Properties of Ipamorelin

Melting point:	144-147°C
Boiling point:	1185.5±65.0 °C(Predicted)
Density	1.263±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Acetonitrile (Slightly, Heated), Methanol (Very Slightly), Water (Slightly)
form	Solid
pka	13.04±0.46(Predicted)
color	White to Off-White

Safety information for Ipamorelin

Computed Descriptors for Ipamorelin

InChIKey	NEHWBYHLYZGBNO-BVEPWEIPSA-N
SMILES	C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(=O)[C@H](CC1N=CNC=1)NC(=O)[C@](C)(C)N