TYRPHOSTIN A51

Synonym(s):2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene

CAS NO.：122520-90-5
Empirical Formula: C13H8N4O3
Molecular Weight: 268.23
MDL number: MFCD00133903
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 15:00:32

What is TYRPHOSTIN A51?

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC₅₀ value of 0.8 μM in the human epidermoid carcinoma cell line A431.

The Uses of TYRPHOSTIN A51

Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3..

What are the applications of Application

Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3.

Definition

ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol.

References

[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398.

Properties of TYRPHOSTIN A51

Melting point:	275 °C
Boiling point:	788.2±60.0 °C(Predicted)
Density	1.591±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
pka	8.46±0.15(Predicted)
form	Orange solid.

Safety information for TYRPHOSTIN A51

Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.