TYRPHOSTIN A51
Synonym(s):2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene
- CAS NO.：122520-90-5
- Empirical Formula: C13H8N4O3
- Molecular Weight: 268.23
- MDL number: MFCD00133903
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is TYRPHOSTIN A51?
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
The Uses of TYRPHOSTIN A51
Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3..
Definition
ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol.
What are the applications of Application
Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3.
References
[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398.
Properties of TYRPHOSTIN A51
| Melting point: | 275 °C |
| Boiling point: | 788.2±60.0 °C(Predicted) |
| Density | 1.591±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| pka | 8.46±0.15(Predicted) |
| form | Orange solid. |
Safety information for TYRPHOSTIN A51
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for TYRPHOSTIN A51
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