AG 825
Synonym(s):4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide;5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide;AG 825 - CAS 149092-50-2 - Calbiochem;Tyrphostin C15
- CAS NO.：149092-50-2
- Empirical Formula: C19H15N3O3S2
- Molecular Weight: 397.47
- MDL number: MFCD01074971
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is AG 825?
The Uses of AG 825
AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.
The Uses of AG 825
A selective ErbB2 inhibitor
What are the applications of Application
AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer
Definition
ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.
Biological Activity
Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
Storage
Store at +4°C
Properties of AG 825
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| form | Yellow solid |
| color | Light yellow to yellow |
| Sensitive | Light Sensitive |
Safety information for AG 825
Computed Descriptors for AG 825
New Products
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![1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol](https://img.chemicalbook.in/CAS/GIF/649735-46-6.gif)
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