Tubacin

Synonym(s):N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide

CAS NO.：537049-40-4
Empirical Formula: C41H43N3O7S
Molecular Weight: 721.86
MDL number: MFCD18452824
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is Tubacin?

The Uses of Tubacin

Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).

What are the applications of Application

Tubacin is a selective inhibitor of HDAC6 that reversibly inhibits α-tubulin deacetylation

Definition

ChEBI: N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide is a member of 1,3-oxazoles.

Biochem/physiol Actions

Tubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.

Properties of Tubacin

Melting point:	155 - 157°C
storage temp.	-20°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to tan

Safety information for Tubacin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.