Trimethylsilyl Isocyanate

Synonym(s):Isocyanatotrimethylsilane

CAS NO.：1118-02-1
Empirical Formula: C4H9NOSi
Molecular Weight: 115.21
MDL number: MFCD00001993
EINECS: 214-256-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:43:35

What is Trimethylsilyl Isocyanate?

Chemical properties

Clear colorless liquid

The Uses of Trimethylsilyl Isocyanate

Trimethylsilyl isocyanate is used in the preparation of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones. It finds application in the carbamoylation of aromatic hydrocarbons and alcohols. It is also used in the preparation of primary amides from Grignard reagents. Further, it is used in the synthesis of cyclic imides. It is also utilized for the synthesis of trifluoroacetyl isocyanate and cyclic imides. In addition to this, it is employed in the conversion of isocyanates to carbodiimides using cyclopentadienyl Mn(CO)3 catalysis.

Purification Methods

Purify it by repeated fractionation as for the isothiocyanate. [Eaborn J Chem Soc 3077 1950, Beilstein 4 III 1861, 4 IV 4011.]

Properties of Trimethylsilyl Isocyanate

Melting point:	-49°C
Boiling point:	90-92 °C(lit.)
Density	0.851 g/mL at 25 °C(lit.)
refractive index	n20/D 1.396(lit.)
Flash point:	-2 °C
storage temp.	2-8°C
solubility	Miscible with ethers and o-dichlorobenzene.
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	0.867
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	1744962
CAS DataBase Reference	1118-02-1(CAS DataBase Reference)
EPA Substance Registry System	Isocyanatotrimethylsilane (1118-02-1)

Safety information for Trimethylsilyl Isocyanate

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.