Ethyl 4,4,4-trifluoroacetoacetate
Synonym(s):ETFAA;Ethyl 3-oxo-4,4,4-trifluorobutyrate
- CAS NO.：372-31-6
- Empirical Formula: C6H7F3O3
- Molecular Weight: 184.11
- MDL number: MFCD00000424
- EINECS: 206-750-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:22
What is Ethyl 4,4,4-trifluoroacetoacetate?
Chemical properties
Clear liquid
The Uses of Ethyl 4,4,4-trifluoroacetoacetate
Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.
The Uses of Ethyl 4,4,4-trifluoroacetoacetate
Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet
The Uses of Ethyl 4,4,4-trifluoroacetoacetate
Widely used in the synthetic process of medicine, pesticides and organic intermediate.
Flammability and Explosibility
Flammable
Synthesis
With an ethanol solution of sodium ethoxide as a catalyst and in the presence of an organic solvent, ethyl trifluoroacetate and ethyl acetate are subjected to a Claisen condensation reaction, and ethyl 4,4,4-trifluoroacetoacetate is synthesized.
Properties of Ethyl 4,4,4-trifluoroacetoacetate
| Melting point: | -39 °C |
| Boiling point: | 129-130 °C(lit.) |
| Density | 1.259 g/mL at 25 °C(lit.) |
| vapor pressure | 8hPa at 20℃ |
| refractive index | n |
| Flash point: | 84 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 10g/l |
| form | Liquid |
| pka | 7.76±0.10(Predicted) |
| Specific Gravity | 1.259 (20/4℃) |
| color | Clear colorless to slightly yellow |
| PH | 6.2 (10g/l, H2O, 20℃) |
| Water Solubility | 10 g/L (20 ºC) |
| BRN | 608353 |
| CAS DataBase Reference | 372-31-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6) |
| EPA Substance Registry System | Ethyl 4,4,4-trifluoroacetoacetate (372-31-6) |
Safety information for Ethyl 4,4,4-trifluoroacetoacetate
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H302:Acute toxicity,oral H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. |
Computed Descriptors for Ethyl 4,4,4-trifluoroacetoacetate
| InChIKey | OCJKUQIPRNZDTK-UHFFFAOYSA-N |
Ethyl 4,4,4-trifluoroacetoacetate manufacturer
JSK Chemicals
3Y
Phone:+91-9879767984
Whatsapp: +91-9879767970
product: Ethyl 4,4,4-trifluoroacetoacetate, 97% 372-31-6 99%
GLR Innovations
Delhi
product: GLR Innovations Ethyl 4,4,4-Trifluoroacetoacetate, Grade: Technical Grade, Packaging Size: 900ml
SRF LIMITED
Beijing
Phone:91-9650533660
Whatsapp: 91-9650533660
product: Ethyl-4,4,4-trifluoroacetoacetate
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: Ethyl-4,4,4-trifluoroacetoacetate
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