tert-Butyl acetoacetate
Synonym(s):TBAA;ACTB;actba;Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed
- CAS NO.：1694-31-1
- Empirical Formula: C8H14O3
- Molecular Weight: 158.2
- MDL number: MFCD00008811
- EINECS: 216-904-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 22:43:19
What is tert-Butyl acetoacetate?
Chemical properties
liquid
The Uses of tert-Butyl acetoacetate
tert-Butyl acetoacetate is used as intermediate for the syntheses of different organic chemicals. Raw material in pharmaceutical Industry, In agrochemical industry. Reagent for Acyloin synthesis and ?,β - unsaturated ketones synthesis.
The Uses of tert-Butyl acetoacetate
Intermediate for the syntheses of different organic chemicals. Product Data Sheet
General Description
tert-Butyl acetoacetate (t-BAA) is a cheap and easy to store commercial reagent. Reaction demonstrated that the more hindered tert-butyl acetoacetate (t-BAA, la) is ca.15-20-fold more reactive than the more commonly used methyl or ethyl analogs. It is widely employed as an acetoacetylating reagent.
Flammability and Explosibility
Flammable
Biochem/physiol Actions
β-Actin modulates cell growth, migration and the G-actin pool. Mutations in ACTB leads to pleiotropic developmental disorder.
Purification Methods
Distil it under reduced pressure through a short column. [Lawesson et al. Org Synth Coll Vol V 155 1973, Lawesson et al. Org Synth 42 28 1962, Beilstein 3 IV 1536.] HARMFUL VAPOUR.
Properties of tert-Butyl acetoacetate
| Melting point: | -38 °C (lit.) |
| Boiling point: | 71-72 °C/11 mmHg (lit.) |
| Density | 0.954 g/mL at 25 °C (lit.) |
| vapor pressure | 79.32Pa at 25℃ |
| refractive index | n |
| Flash point: | 150 °F |
| storage temp. | -20°C |
| solubility | 9g/l |
| form | Liquid |
| pka | 10.71±0.46(Predicted) |
| color | clear |
| PH | 5.7 (9g/l, H2O, 20℃) |
| explosive limit | 1.1%(V) |
| Water Solubility | Soluble in water (9g/L). |
| BRN | 1680303 |
| CAS DataBase Reference | 1694-31-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Butanoic acid, 3-oxo-, 1,1-dimethylethyl ester(1694-31-1) |
| EPA Substance Registry System | tert-Butyl acetoacetate (1694-31-1) |
Safety information for tert-Butyl acetoacetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for tert-Butyl acetoacetate
| InChIKey | JKUYRAMKJLMYLO-UHFFFAOYSA-N |
tert-Butyl acetoacetate manufacturer
BTC pharm India
5Y
Phone:+91-8790379245
Whatsapp: +91- 6361382515
product: tert-Butyl acetoacetate 98+
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