(TRIISOPROPYLSILYL)ACETYLENE

Synonym(s):Ethynyltriisopropylsilane

CAS NO.：89343-06-6
Empirical Formula: C11H22Si
Molecular Weight: 182.38
MDL number: MFCD00075452
EINECS: 629-580-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-28 19:59:05

(TRIISOPROPYLSILYL)ACETYLENE Structural Picture

What is (TRIISOPROPYLSILYL)ACETYLENE?

The Uses of (TRIISOPROPYLSILYL)ACETYLENE

(Triisopropylsilyl)acetylene (TIPS-acetylene) is an easily handled and inexpensive monoprotected acetylene used as an attractive substitute for trimethylsilylacetylene (TMSacetylene). The bulkier silyl protecting group of TIPS-acetylene provides stability in a wider range of reaction conditions than TMS-acetylene. Its higher boiling point also provides better handling and safety than TMS-acetylene (bp 87–88°C at 12 hPa (9 mmHg)). The general utility of TIPS-acetylene is often highlighted in the transition metal-catalyzed C–C bond formations， including but not limited to transition metal-catalyzed Coupling Reactions；Reaction of TIPS-acetylide with Electrophiles；Synthesis of Polyynes；Transition Metal-catalyzed Cross-addition of TIPSacetylene to Alkynes；Hydroalkynylation；Direct Alkynylation；Conjugate Addition；Cycloaddition；Ring-opening Reactions etc.

What are the applications of Application

(Triisopropylsilyl)acetylene is an addition and alkynylation synthesis reagent

Properties of (TRIISOPROPYLSILYL)ACETYLENE

Melting point:	50-51 °C
Boiling point:	50-52 °C/0.6 mmHg (lit.)
Density	0.813 g/mL at 25 °C (lit.)
Flash point:	133 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Miscible with organic solvents.

Safety information for (TRIISOPROPYLSILYL)ACETYLENE

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.