Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid

CAS NO.：69907-67-1
Empirical Formula: C12H15NO4
Molecular Weight: 237.25
MDL number: MFCD11519178
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-08 17:45:00

What is Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid?

Description

Trans-4-(Maleimidomethyl) cyclohexanecarboxylic Acid is a kind of carboxylate, being well known for its N-hydroxysuccinimide ester derivative (SMCC), which is a useful cross-linking reagent. SMCC is widely used for the generation of stable maleimide-activated carrier proteins, enzyme immunoconjugates and hapten carrier molecule conjugates. It can be used for the coupling of a peptide to an amino group.

References

https://www.aatbio.com/products/smcc-4-n-maleimidomethyl-cyclohexanecarboxylic-acid-n-hydroxysuccinimide-ester-cas-64987-85-5
http://www.sigmaaldrich.com/catalog/product/sigma/m5525?lang=en&region=US
Zhang, Hongyan, et al. "Antifreeze protein detection using Rhodamine B as photoluminescence label inporous silicon." Current Applied Physics13.4(2013):736-742.

Properties of Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid

Melting point:	144 °C(Solv: benzene (71-43-2))
Boiling point:	433.6±18.0 °C(Predicted)
Density	1.329
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	4.80±0.10(Predicted)
form	powder to crystal
color	White to Almost white
CAS DataBase Reference	69907-67-1

Safety information for Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.