trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS NO.：848133-35-7
- Empirical Formula: C6H12ClNO2
- Molecular Weight: 165.62
- MDL number: MFCD03695466
- EINECS: 617-631-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:33:46
What is trans-4-Dimethylaminocrotonic acid hydrochloride?
Description
trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.
Chemical properties
White Solid
The Uses of trans-4-Dimethylaminocrotonic acid hydrochloride
trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.
What are the applications of Application
trans 4-Dimethylaminocrotonic acid hydrochloride is a precursor to tyrosine kinase inhibiting antitumor agents
Synthesis
trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.
Properties of trans-4-Dimethylaminocrotonic acid hydrochloride
| Melting point: | 162 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+; |
| CAS DataBase Reference | 848133-35-7(CAS DataBase Reference) |
Safety information for trans-4-Dimethylaminocrotonic acid hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for trans-4-Dimethylaminocrotonic acid hydrochloride
| InChIKey | UUHNQHFOIVLAQX-BJILWQEISA-N |
| SMILES | C(/CN(C)C)=C\C(=O)O.Cl |
trans-4-Dimethylaminocrotonic acid hydrochloride manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: trans-4-Dimethylaminocrotonic acid hydrochloride
Akshaya Pure Chemicals
Mumbai
product: Powder 99% Trans 4-Dimethylaminocrotonic Acid HCl, 848133-35-7
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