trans-4-Dimethylaminocrotonic acid hydrochloride

CAS NO.：848133-35-7
Empirical Formula: C6H12ClNO2
Molecular Weight: 165.62
MDL number: MFCD03695466
EINECS: 617-631-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 16:04:00

What is trans-4-Dimethylaminocrotonic acid hydrochloride?

Description

trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.

Chemical properties

White Solid

The Uses of trans-4-Dimethylaminocrotonic acid hydrochloride

trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.

What are the applications of Application

trans 4-Dimethylaminocrotonic acid hydrochloride is a precursor to tyrosine kinase inhibiting antitumor agents

Synthesis

trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.

Properties of trans-4-Dimethylaminocrotonic acid hydrochloride

Melting point:	162 °C
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+;
CAS DataBase Reference	848133-35-7(CAS DataBase Reference)

Safety information for trans-4-Dimethylaminocrotonic acid hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.