tolycaine
- CAS NO.：3686-58-6
- Empirical Formula: C15H22N2O3
- Molecular Weight: 278.35
- MDL number: MFCD00864442
- EINECS: 222-976-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:01
What is tolycaine?
Originator
Tolycaine Hydrochloride,ZYF Pharm Chemical
Definition
ChEBI: Tolycaine is an amidobenzoic acid.
Manufacturing Process
A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of
benzene was added 125 ml of saturated solution of sodium acetate and then
at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1
hour at room temperature. The mixture was filtered. The organic layer was
with 10% solution of potassium carbonate and dries under calcium chloride.
By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from
a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl
ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After
cooling the diethyl amine hydrochloride was deleted by filtration. The organic
layer was washed with 2 N hydrochloric acid. To the solution was added
potassium carbonate. The product was extracted with ether and distilled.
brand name
Tolycaine Hydrochloride is JAN.
Therapeutic Function
Local anesthetic
Properties of tolycaine
| Melting point: | <25 °C |
| Boiling point: | bp5 190-192° |
| Density | 1.113±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 100 mg/mL (359.26 mM) |
| pka | 13.61±0.70(Predicted) |
| form | Liquid |
| color | Light yellow to yellow |
Safety information for tolycaine
Computed Descriptors for tolycaine
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