Thioflavine S

The Uses of Thioflavine S

Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain. Dyes and metabolites.

What are the applications of Application

Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain

Preparation

(a) primrose spirit alkali (C.I.Direct Yellow 59, C.I. 49000) methylation, then will be preparing sulphonated product (GP 1251738); (b) primrose spirit alkali stlfonation, then will product methylation (GP 53333).

Definition

ChEBI: Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome, a histological dye and a geroprotector. It contains a thioflavin T cation.

Properties and Applications

green light yellow. For golden is soluble in water, but soluble in ethanol as a green fluorescent yellow. The strong sulfuric acid in nearly colorless, with blue fluorescence, after diluted orange yellow precipitation. Used for cellulose fiber, wool, silk dyeing, silk printing, also can be used for leather color. Exhaust dyeing, good levelness.