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HomeProduct name listTETRANOR-12(S)-HETE

TETRANOR-12(S)-HETE

TETRANOR-12(S)-HETE Structural

What is TETRANOR-12(S)-HETE?

Description

12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound.

What are the applications of Application

tetranor-12(S)-HETE is a derivative of 12(S)-HETE

Definition

ChEBI: Tetranor 12-HETE is a hydroxy fatty acid.

Properties of TETRANOR-12(S)-HETE

storage temp.  Store at -20°C
solubility  0.1 M Na2CO3: 2 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .5 mg/ml

Safety information for TETRANOR-12(S)-HETE

Computed Descriptors for TETRANOR-12(S)-HETE

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Related products of tetrahydrofuran

TETRANOR-12(S)-HETE
TETRANOR-12(S)-HETE
12(S)-HETE
12(S)-HETE

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