TETRACHLOROHYDROQUINONE

Description

Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC₅₀ = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.

Chemical properties

LIGHT BEIGE CRYSTALLINE POWDER

The Uses of TETRACHLOROHYDROQUINONE

Tetrachlorohydroquinone is a chlorinated hydroquinone compound used as an analytical standard.

Definition

ChEBI: A tetrachlorobenzene that is 1,2,4,5-tetrachlorobenzene in which the hydrogens at positions 3 and 6 are replaced by hydroxy groups.

What are the applications of Application

Tetrachlorohydroquinone is a tchlorinated hydroquinone compound used as an analytical standard

Purification Methods

Crystallise the quinone from EtOH or AcOH/EtOH. Sublime it at 77o/0.6x10-3mm. The dibenzoyl derivative has m 233o. [Conant & Fieser J Am Chem Soc 45 2207 1923, Rabideau et al. J Am Chem Soc 108 8130 1986, Beilstein 6 H 851, 6 I 417, 6 II 846, 6 III 4436, 6 IV 5775.]