2,3,5,6-TETRACHLOROPHENOL

CAS NO.：935-95-5
Empirical Formula: C6H2Cl4O
Molecular Weight: 231.89
MDL number: MFCD00044671
EINECS: 213-310-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-10 10:27:19

What is 2,3,5,6-TETRACHLOROPHENOL?

Chemical properties

Brown solid; phenol odor. Soluble in sodium hydroxide solutions and most organic solvents; insoluble in water.

The Uses of 2,3,5,6-TETRACHLOROPHENOL

Fungicide, wood preservative.

Definition

ChEBI: The 2,3,5,6-isomer of tetrachlorophenol

Production Methods

Chlorophenols are generally prepared by the chlorination of phenol. There are other routes of synthesis as through diazotizing p-chloroaniline or dechlorinating (by alkaline hydrolysis) 1,2,4,5-tetrachlorobenzene to yield 2,4,5-trichlorophenol (TCP). Polychlorinated dibenzo-p-dioxins can be formedduringthemanufacturingprocess of the chlorophenols. The amount formed depends on temperature and pressure process variability during production. The more notable toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), is formed during the production of 2,4,5- TCP. Laboratory reference standards of 2,3,7,8-TCDD are prepared by heating 2,4,5-TCP under alkaline conditions. All technical and formulated products containing 2,4,5-TCP are expected to be contaminated to varying degrees by this 2,3,7,8-TCDD by-product of the manufacturing process.

General Description

Leaflets (from ligroin) or light beige powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,3,5,6-TETRACHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents. .

Hazard

Toxic by ingestion and inhalation, strong irritant.

Fire Hazard

Flash point data for 2,3,5,6-TETRACHLOROPHENOL are not available. 2,3,5,6-TETRACHLOROPHENOL is probably combustible.

Carcinogenicity

There was no evidence of carcinogenic activity of 2,4-dichlorophenol in F344/N rats or B6C3F1 mice from the NTP bioassay program, but 2,4,6-trichlorophenol was reported to be carcinogenic in both species.

Purification Methods

Crystallise the phenol from pet ethers. The benzoate has m 136o (from EtOH). [Beilstein 6 II 182, 6 III 730, 6 IV 1025.]

Properties of 2,3,5,6-TETRACHLOROPHENOL

Melting point:	115-116℃ (isooctane )
Boiling point:	331.59°C (rough estimate)
Density	1.6 g/cm3 (60℃)
refractive index	1.5133 (estimate)
Flash point:	11 °C
storage temp.	APPROX 4°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	5.09±0.20(Predicted)
form	neat
Water Solubility	0.1g/L(25 ºC)
BRN	2049586
CAS DataBase Reference	935-95-5(CAS DataBase Reference)
EPA Substance Registry System	2,3,5,6-Tetrachlorophenol (935-95-5)

Safety information for 2,3,5,6-TETRACHLOROPHENOL

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.