tert-Butyl 2-(dimethoxyphosphoryl)acetate
Synonym(s):tert-Butyl ((oxo)dimethoxyphosphino)acetate;tert-Butyl (dimethoxyphosphinyl)acetate;Dimethyl (tert-butoxycarbonyl)methylphosphonate
- CAS NO.：62327-21-3
- Empirical Formula: C8H17O5P
- Molecular Weight: 224.19
- MDL number: MFCD00042939
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:36
What is tert-Butyl 2-(dimethoxyphosphoryl)acetate?
The Uses of tert-Butyl 2-(dimethoxyphosphoryl)acetate
Reactant for:
- Preparation of phosphonate terminated PPH dendrimers as anti-HIV-1 agents
- Preparation of monodehydro diketopiperazines from ketoacyl amino acid amides via acid-catalyzed cyclization
- Preparation of α,β-unsaturated esters for use in the guanidine-catalyzed oxa-Michael addition
- Preparation of myxopyronin B and desmethyl myxopyronin B analogs, with antibacterial activity and inhibitory activity against bacterial RNA polymerase
- Allylation and subsequent ring-closing metathesis in presence of Grubbs′ catalyst or intramolecular rhodium-catalyzed cyclopropanation reactions
What are the applications of Application
tert-Butyl P,P-dimethylphosphonoacetate is a Horner-Wittig reagent giving preferentially (E)-α,β-unsat. esters which are mildly saponified with acid
Properties of tert-Butyl 2-(dimethoxyphosphoryl)acetate
| Boiling point: | 86-87 °C0.02 mm Hg(lit.) |
| Density | 1.131 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 110 ºC |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| color | Colorless to Almost colorless |
| BRN | 4861886 |
| InChI | InChI=1S/C8H17O5P/c1-8(2,3)13-7(9)6-14(10,11-4)12-5/h6H2,1-5H3 |
Safety information for tert-Butyl 2-(dimethoxyphosphoryl)acetate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for tert-Butyl 2-(dimethoxyphosphoryl)acetate
| InChIKey | SAZYDWOWLRDDRQ-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)CP(OC)(OC)=O |
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