SUFUGOLIX
- CAS NO.：308831-61-0
- Empirical Formula: C36H31F2N5O4S
- Molecular Weight: 667.72
- MDL number: MFCD09837896
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is SUFUGOLIX?
Description
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM). Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM). Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.
Properties of SUFUGOLIX
| Density | 1.383±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C,unstable in solution, ready to use. |
| solubility | DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL |
| form | A solid |
| pka | 13.20±0.70(Predicted) |
| color | Light yellow to yellow |
Safety information for SUFUGOLIX
Computed Descriptors for SUFUGOLIX
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