SR-95531

Synonym(s):2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide;GABA _A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531;GABA_A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531;Gabazine;SR95531 (Gabazine) - CAS 104104-50-9 - Calbiochem

CAS NO.：104104-50-9
Empirical Formula: C15H18BrN3O3
Molecular Weight: 368.23
MDL number: MFCD09055424
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is SR-95531?

Description

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABA_A receptors (K_i = 74-150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone. It is effective against GABA_A receptor isoforms from mice, rats, and humans.

The Uses of SR-95531

Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.

What are the applications of Application

SR 95531 Hydrobromide is a selective GABAA receptor antagonist

Biological Activity

Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

Storage

Room temperature

Properties of SR-95531

Melting point:	200 °C(Solv: ethanol (64-17-5))
storage temp.	Store at RT
solubility	DMSO: 30 mg/mL
form	solid
color	white

Safety information for SR-95531

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.