SR 11302

Description

The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE. Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1). SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE. It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 μM). SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.

The Uses of SR 11302

SR 11302 is an inhibitor of activator protein-1.

What are the applications of Application

SR 11302 is an inhibitor of activator protein-1

Biological Activity

Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC 50 > 1 μ M for RAR α , RAR β , RAR γ and RXR α ).

Storage

Store at -20°C