sodium 5-(sec-butyl)-5-ethylbarbiturate

Originator

Butisol sodium,Wallace Labs,USA

The Uses of sodium 5-(sec-butyl)-5-ethylbarbiturate

Sedative-hypnotic.

Manufacturing Process

5-sec-Butyl-5-ethylbarbituric acid was prepared from diethyl ester of malonic acid in 3 steps. At the above malonic ester was reacted with C2H5Br and sodium ethylate producing the diethyl ester of ethylmalonic acid, which after a reaction with sodium ethylate and 2-butylbromide gave the ethyl-(2-butyl)- malonic acid diethyl ester. The last one produced the 5-sec-butyl-5-ethylbarbituric acid after a reaction with urea and sodium ethylate.
23 g sodium (1 mol) was dissolved in 300 ml alcohol. To this solution was added a solution of 5-sec-butyl-5-ethyl-barbituric acid (1 mol) in 800 ml alcohol. To a mixture was added 1000 ml benzene, which precipitated the sodium salt of the barbituric acid (butabarbital sodium). The product was filtered and dried.

brand name

Butabarb (Alpharma); Butalan (Lannett); Buticaps (Medpointe); Butisol Sodium (Medpointe); Sarisol (Halsey).

Therapeutic Function

Hypnotic