Sb-742457
- CAS NO.：607742-69-8
- Empirical Formula: C19H19N3O2S
- Molecular Weight: 353.44
- MDL number: MFCD12828872
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is Sb-742457?
Description
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.
The Uses of Sb-742457
SB 742457 is a selective 5-HT6 receptor antagonist which is known to be involved in improving cognitive function.
References
[1] aaron t. t. chuang, andrew foley, perdita l. pugh, david sunter, xin tong, ciaran regan, lee a. dawson, andrew d. medhurst, neil upton.5-ht6 receptor antagonist sb-742457 as a novel cognitive enhancing agent for alzheimer’s disease. alzheimer's & dementia: the journal of the alzheimer's association volume 2, issue 3, supplement, pages s631–s632, july 2006
Properties of Sb-742457
| Boiling point: | 608.3±45.0 °C(Predicted) |
| Density | 1.292 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 8?+-.0.10(Predicted) |
| color | Light yellow to yellow |
Safety information for Sb-742457
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Sb-742457
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
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