SB242235
- CAS NO.：193746-75-7
- Empirical Formula: C19H20FN5O
- Molecular Weight: 353.39
- MDL number: MFCD08690575
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is SB242235?
Biological Activity
SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.
in vitro
SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.
Western Blot Analysis
| Cell Line: | Human chondrocytes |
| Concentration: | 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM |
| Incubation Time: | < td class="col2"> 15 minutes|
| Result: | Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM. |
Properties of SB242235
| Boiling point: | 568.4±60.0 °C(Predicted) |
| Density | 1.34 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml |
| form | Powder |
| pka | 9.91±0.10(Predicted) |
| color | White to off-white |
Safety information for SB242235
Computed Descriptors for SB242235
New Products
Cyclopropane-1,1-dicarboxylic acid Cyclopentane-1,2-dione 2-Bromo-5-iodopyridine 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Amino-4-methoxyben-zeneacetic acid 3-Aminophenylacetic acid 1-AMino-cyclobutaneMethanol HCl (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 3-Hydroxypropionitrile valeronitrile 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 2-Chloro Benzylcyanide 4-Bromo Benzylcyanide 5-azidovalericacid 4-bromo-1H-pyrazole-3-carboxylic acid Isopropyl amine Hydrochloride tert-butyl 4-(6-(8-cyclopentyl-5-methyl-7-oxo-6-vinyl-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazine-1-carboxylateRelated products of tetrahydrofuran
![2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride](https://img.chemicalbook.in/CAS/GIF/694433-59-5.gif)
![6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline](https://img.chemicalbook.in/CAS/GIF/356559-20-1.gif)
You may like
-
SB-242235 >95% CAS 193746-75-7View Details
193746-75-7 -
4-cyano-2,2-dimethylbutanoic acid 6939-69-1 98+View Details
6939-69-1 -
1-(cyanomethyl)-1-cyclopentanecarbonitrile 98+View Details
1539-03-3 -
tert-butyl(R)-4-(methyl(1-(pyrrolidin-3-yl)cyclopropyl)amino)piperidine-1-carboxylate 922718-06-7 98+View Details
922718-06-7 -
39773-47-2 (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 98+View Details
39773-47-2 -
1392213-15-8 98+View Details
1392213-15-8 -
39773-47-2 (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 98+View Details
39773-47-2 -
1392213-15-8 98+View Details
1392213-15-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.