SB 204741

Synonym(s):N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

CAS NO.：152239-46-8
Empirical Formula: C14H14N4OS
Molecular Weight: 286.35
MDL number: MFCD00923644
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-07 19:09:50

What is SB 204741?

The Uses of SB 204741

SB 204741 is a potent, selective SR-2B antagonist.

What are the applications of Application

SB 204741 is a potent, selective SR-2B antagonist

Definition

ChEBI: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea is a member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It is a member of ureas, a member of indoles and a member of 1,2-thiazoles.

Biological Activity

Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.

Storage

Room temperature

Properties of SB 204741

Melting point:	>195°C (dec.)
storage temp.	2-8°C
solubility	DMSO: ~18 mg/mL, soluble
form	solid
color	orange
Stability:	Hygroscopic

Safety information for SB 204741

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.