SB 204741
Synonym(s):N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea
- CAS NO.：152239-46-8
- Empirical Formula: C14H14N4OS
- Molecular Weight: 286.35
- MDL number: MFCD00923644
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is SB 204741?
The Uses of SB 204741
SB 204741 is a potent, selective SR-2B antagonist.
What are the applications of Application
SB 204741 is a potent, selective SR-2B antagonist
Definition
ChEBI: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea is a member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It is a member of ureas, a member of indoles and a member of 1,2-thiazoles.
Biological Activity
Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.
Storage
Room temperature
Properties of SB 204741
| Melting point: | >195°C (dec.) |
| storage temp. | 2-8°C |
| solubility | DMSO: ~18 mg/mL, soluble |
| form | solid |
| color | orange |
| Stability: | Hygroscopic |
Safety information for SB 204741
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SB 204741
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 2,4-Dihydroxybenzaldehyde Dipropyl disulfide Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Obidoxime hydrochloride API 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-NitrobenzotrifluorideRelated products of tetrahydrofuran
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