GSK-CXCR2
Synonym(s):1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea;N-(2-Bromophenyl)-N′-(7-cyano-1H-benzotriazol-4-yl)urea;SB 265610
- CAS NO.：211096-49-0
- Empirical Formula: C14H9BrN6O
- Molecular Weight: 357.16
- MDL number: MFCD09971124
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is GSK-CXCR2?
The Uses of GSK-CXCR2
SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
What are the applications of Application
SB 265610 is a potent CXCR2 antagonist
Biological Activity
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
Biochem/physiol Actions
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
Storage
Store at RT
Properties of GSK-CXCR2
| Boiling point: | 527.0±45.0 °C(Predicted) |
| Density | 1.77±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 6.13±0.40(Predicted) |
| color | white to light brown |
Safety information for GSK-CXCR2
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for GSK-CXCR2
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