(S)-Oxiranemethanol
Synonym(s):(S)-(−)-2,3-Epoxy-1-propanol;(S)-(−)-Oxirane-2-methanol
- CAS NO.：60456-23-7
- Empirical Formula: C3H6O2
- Molecular Weight: 74.08
- MDL number: MFCD00074874
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:16:46
What is (S)-Oxiranemethanol?
Chemical properties
Colorless to light yellow liqui
The Uses of (S)-Oxiranemethanol
Employed in the synthesis of chiral (E)-allylic alcohol side-chains for introduction into prostacyclin and prostaglandin frameworks by cross-metathesis.
What are the applications of Application
(S)-(?)-Glycidol is a chemical employed in the synthesis of chiral (E)-allylic alcohol side-chains
Definition
ChEBI: (S)-glycidol is a glycidol. It is functionally related to a (S)-1,2-epoxypropane. It is an enantiomer of a (R)-glycidol.
General Description
Glycidol or 2,3-epoxy-1-propanol is a highly reactive epoxy derivative, which is generally used as a monomer in the preparation of many polymers like polyesters,?polycarbonates,?polyurethanes,?and polyamides. It is also used in the preparation of detergents, rubbers, perfumes, fabric dyes, varnishes, cosmetics, and paints.
Purification Methods
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.
Properties of (S)-Oxiranemethanol
| Melting point: | 72-73 °C |
| alpha | -15 º (neat) |
| Boiling point: | 66-67 °C19 mm Hg(lit.) |
| Density | 1.116 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | 178 °F |
| storage temp. | -20°C |
| solubility | Soluble in chloroform, DMSO and methanol. |
| form | Liquid |
| pka | 14.62±0.10(Predicted) |
| color | Pale yellow |
| optical activity | [α]20/D 15°, neat |
| BRN | 79783 |
| CAS DataBase Reference | 60456-23-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Oxiranemethanol, (S)-(60456-23-7) |
Safety information for (S)-Oxiranemethanol
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H341:Germ cell mutagenicity H350:Carcinogenicity |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-Oxiranemethanol
| InChIKey | CTKINSOISVBQLD-VKHMYHEASA-N |
New Products
Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine HydrochlorideRelated products of tetrahydrofuran
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