(S)-Oxiranemethanol

Synonym(s):(S)-(−)-2,3-Epoxy-1-propanol;(S)-(−)-Oxirane-2-methanol

CAS NO.：60456-23-7
Empirical Formula: C3H6O2
Molecular Weight: 74.08
MDL number: MFCD00074874
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is (S)-Oxiranemethanol?

Chemical properties

Colorless to light yellow liqui

The Uses of (S)-Oxiranemethanol

Employed in the synthesis of chiral (E)-allylic alcohol side-chains for introduction into prostacyclin and prostaglandin frameworks by cross-metathesis.

What are the applications of Application

(S)-(?)-Glycidol is a chemical employed in the synthesis of chiral (E)-allylic alcohol side-chains

Definition

ChEBI: (S)-glycidol is a glycidol. It is functionally related to a (S)-1,2-epoxypropane. It is an enantiomer of a (R)-glycidol.

General Description

Glycidol or 2,3-epoxy-1-propanol is a highly reactive epoxy derivative, which is generally used as a monomer in the preparation of many polymers like polyesters,?polycarbonates,?polyurethanes,?and polyamides. It is also used in the preparation of detergents, rubbers, perfumes, fabric dyes, varnishes, cosmetics, and paints.

Purification Methods

[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.

Properties of (S)-Oxiranemethanol

Melting point:	72-73 °C
alpha	-15 º (neat)
Boiling point:	66-67 °C19 mm Hg(lit.)
Density	1.116 g/mL at 20 °C(lit.)
refractive index	n20/D 1.433(lit.)
Flash point:	178 °F
storage temp.	-20°C
solubility	Soluble in chloroform, DMSO and methanol.
form	Liquid
pka	14.62±0.10(Predicted)
color	Pale yellow
optical activity	[α]20/D 15°, neat
BRN	79783
CAS DataBase Reference	60456-23-7(CAS DataBase Reference)
NIST Chemistry Reference	Oxiranemethanol, (S)-(60456-23-7)

Safety information for (S)-Oxiranemethanol

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H341:Germ cell mutagenicity H350:Carcinogenicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.