S-(4-Nitrobenzyl)-6-thioinosine

Chemical properties

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The Uses of S-(4-Nitrobenzyl)-6-thioinosine

S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.

The Uses of S-(4-Nitrobenzyl)-6-thioinosine

It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio

What are the applications of Application

S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is an inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties

Definition

ChEBI: NBMPR is a purine nucleoside.

General Description

S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S⁶-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

Biological Activity

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Biochem/physiol Actions

Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.

Storage

Store at +4°C