(S)-(-)-4-Amino-2-hydroxybutyric acid

CAS NO.：40371-51-5
Empirical Formula: C4H9NO3
Molecular Weight: 119.12
MDL number: MFCD00674110
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-08 10:32:36

What is (S)-(-)-4-Amino-2-hydroxybutyric acid?

Chemical properties

white to light yellow crystal powder

The Uses of (S)-(-)-4-Amino-2-hydroxybutyric acid

(S)-(-)-4-Amino-2-hydroxybutyric Acid is an analogue of γ-aminobutyric acid (GABA) with potential inhibitory activity on GABA binding and uptake by brain. Injection of (S)-(-)-4-Amino-2-hydroxybutyric Acid showed no significant changes in plasma growth hormone (GH) in healthy patients but increased plasma GH, prolactin, and cortisol levels in cerebrovascular patients.

The Uses of (S)-(-)-4-Amino-2-hydroxybutyric acid

(S)-(-)-4-Amino-2-hydroxybutyric acid may be used in the preparation of 6′-amino-1-N-[(S)-4-amino-2-hydroxybutyryl]-6′-deoxylividomycin A.

What are the applications of Application

(S)-(?)-4-Amino-2-hydroxybutyric acid is a building block for enantiopure 3-hydroxypyrrolidin-2-ones

General Description

(S)-(-)-4-Amino-2-hydroxybutyric acid is an important moiety of butirosin, an aminoglycoside antibiotic.

Properties of (S)-(-)-4-Amino-2-hydroxybutyric acid

Melting point:	200-203 °C (lit.)
Boiling point:	222.38°C (rough estimate)
alpha	-30 º (c=1, water)
Density	1.3126 (rough estimate)
refractive index	-30 ° (C=1, H2O)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Methanol (Very Slightly, Heated), Water
form	Crystalline Powder, Crystals and/or Chunks
pka	3.47±0.10(Predicted)
color	White to beige
optical activity	[α]23/D 30°, c = 1 in H2O
Water Solubility	almost transparency
Sensitive	Hygroscopic
Stability:	Hygroscopic
CAS DataBase Reference	40371-51-5(CAS DataBase Reference)

Safety information for (S)-(-)-4-Amino-2-hydroxybutyric acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.