(S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate

Synonym(s):(S)-2,2-Dimethyl-1,3-dioxolane-4-methyl p-toluenesulfonate;L-α,β-Isopropylideneglycerol-γ-tosylate;2,3-Isopropylidene-sn-glycerol 1-tosylate;2,3-Isopropylidene-sn-glycerol 1-tosylate

CAS NO.：23735-43-5
Empirical Formula: C13H18O5S
Molecular Weight: 286.34
MDL number: MFCD00063234
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:13:49

(S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate Structural

What is (S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate?

Chemical properties

white to light yellow crystal powde

The Uses of (S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate

(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate has been used as a reactant for the synthesis of 16-(3-trifluoromethyl)phenoxy PGF2α analog travoprost (T715600) which has potent topical ocular activity. (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate has also been used for the preparation of p38 mitogen activated protein (MAP) kinase inhibitors.

Properties of (S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate

Melting point:	29-31 °C
Boiling point:	398.71°C (rough estimate)
alpha	4.2 º (c=10, abs.alcohol)
Density	1.208 g/mL at 25 °C(lit.)
refractive index	n20/D 1.506(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,2-8°C
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
optical activity	[α]26/D +7.5°, c = 2% in DMF
BRN	89799
CAS DataBase Reference	23735-43-5(CAS DataBase Reference)

Safety information for (S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.