(S)-1-(4-Nitrophenyl)ethylamine hydrochloride
Synonym(s):(R)-1-(4-Nitrophenyl)ethylamine hydrochloride
- CAS NO.：57233-86-0
- Empirical Formula: C8H11ClN2O2
- Molecular Weight: 202.64
- MDL number: MFCD00066311
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:38
What is (S)-1-(4-Nitrophenyl)ethylamine hydrochloride?
Purification Methods
To ensure dryness, the hydrochloride (ca 175 g) is extracted with EtOH (3x100mL) and evaporated to dryness (any residual H2O increases the solubility in EtOH and lowers the yield). The hydrochloride residue is triturated with absolute EtOH and dried in vacuo. The product is further purified by refluxing with absolute EtOH (200 mL for 83g) for 1hour, and cool to 10o to give 76.6g of hydrochloride m 243-245o(dec). The free base is prepared by dissolving in N NaOH, extracting with CH2Cl2 (3 x 500mL), drying (Na2CO3), filtering, evaporating and distilling it. It has m 27o, b 119-120o/0.5mm (105-107o/0.5mm, 157-159o/9mm, d 1.1764, n 1.5688, [] ±17.7o (neat) [Perry et al. Synthesis 492 1977,ORD: Nerdel & Liebig Justus Liebigs Ann Chem 621 142 1959]. [Beilstein 12 IV 2451.]
Properties of (S)-1-(4-Nitrophenyl)ethylamine hydrochloride
| Melting point: | 248-250 °C(lit.) |
| alpha | -6.5 º (c=1, 0.05N NaOH) |
| storage temp. | Inert atmosphere,Room Temperature |
| optical activity | [α]25/D +6.0°, c = 1 in 0.05 M NaOH |
| BRN | 3701567 |
| CAS DataBase Reference | 57233-86-0(CAS DataBase Reference) |
Safety information for (S)-1-(4-Nitrophenyl)ethylamine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-1-(4-Nitrophenyl)ethylamine hydrochloride
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