Rutamycin

CAS NO.：1404-59-7
Empirical Formula: C44H72O11
Molecular Weight: 777.042
MDL number: MFCD32640222
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:25

What is Rutamycin?

Description

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F₁F_O-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC₅₀ value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC₅₀ value of 36 μM.

The Uses of Rutamycin

Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

The Uses of Rutamycin

Oligomycin D is an inhibitor of mitochondrial F1F0-ATPase.

What are the applications of Application

Oligomycin D is Oligomycin D (rutamycin) is an inhibitor of mitochondrial F1F0-ATPase

Properties of Rutamycin

Melting point:	116-119°
alpha	D20 -62° (c = 1.36 in CHCl3)
Boiling point:	883.4±65.0 °C(Predicted)
Density	1.15±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form	A lyophilisate
pka	12.52±0.70(Predicted)