RU 58668
- CAS NO.：151555-47-4
- Empirical Formula: C34H43F5O5S
- Molecular Weight: 658.76
- MDL number: MFCD00923194
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 17:10:26
What is RU 58668?
The Uses of RU 58668
RU 58668 is a pure antiestrogen.
What are the applications of Application
RU 58668 is a pure antiestrogen
Definition
ChEBI: A 17beta-hydroxy steroid that is 17beta-estradiol in the the hydrogen at the 11beta position has been replaced by a p-({5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl}oxy)phenyl group. RU 586 8 is a pure anti-estrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM).
Biological Activity
Pure antiestrogen that downregulates estrogen receptor expression (IC 50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC 50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo .
Properties of RU 58668
| storage temp. | Store at +4°C |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| form | Powder |
Safety information for RU 58668
Computed Descriptors for RU 58668
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