RO-32-0432

Synonym(s):3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride;3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride;Bisindoylmaleimide XI

CAS NO.：151342-35-7
Empirical Formula: C28H28N4O2
Molecular Weight: 452.55
MDL number: MFCD01319127
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-28 16:00:23

What is RO-32-0432?

The Uses of RO-32-0432

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic infl ammatory responses in vivo.

Biological Activity

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca 2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α , β Ι, β ΙΙ, γ and ε respectively. Orally available and prevents T-cell chronic inflammation in vivo .

Properties of RO-32-0432

Boiling point:	712.2±60.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO: soluble
form	solid
pka	7.91±0.60(Predicted)
color	orange