RKI1447

CAS NO.：1342278-01-6
Empirical Formula: C16H14N4O2S
Molecular Weight: 326.37
MDL number: MFCD26142658
EINECS: 200-256-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is RKI1447?

Description

RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC₅₀s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC₅₀ = 709 nM).

The Uses of RKI1447

RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.

References

[1] patel r a et al. , rki-1447 is a potent inhibitor of the rho-associated rock kinases with anti-invasive and antitumor activities in breast cancer. cancer res, 2012, 72(19): 5025-5034.

Properties of RKI1447

Melting point:	>205oC (dec.)
Density	1.408±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	6.36±0.70(Predicted)
color	Pale Yellow to Pale Beige

Safety information for RKI1447

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.