RIBOSTAMYCIN SULFATE SALT
- CAS NO.：25546-65-0
- Empirical Formula: C17H34N4O10
- Molecular Weight: 454.47
- MDL number: MFCD00057496
- EINECS: 247-091-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-18 09:51:22
What is RIBOSTAMYCIN SULFATE SALT?
Description
Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections.
Background
Ribostamycin is an aminoglycoside antibiotic isolated from Streptomyces ribosidificus listed as one of the World Health Organization's critically important antimicrobials.
Definition
ChEBI: An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attache at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).
Mechanism of action
Ribostamycin (SF-733) is produced by Streptomyces ribosidificus. The free base is crystallized from methanol solution. The structure has been determined by chemical methods and total synthesis has been undertaken .
Metabolism
Not Available
Properties of RIBOSTAMYCIN SULFATE SALT
| Melting point: | 192-195°; mp 175-180° (dec) |
| Boiling point: | 561.28°C (rough estimate) |
| alpha | D23 +42° |
| Density | 1.1751 (rough estimate) |
| refractive index | 1.6700 (estimate) |
| storage temp. | 2-8°C |
| pka | 7.70(at 25℃) |
Safety information for RIBOSTAMYCIN SULFATE SALT
Computed Descriptors for RIBOSTAMYCIN SULFATE SALT
RIBOSTAMYCIN SULFATE SALT manufacturer
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