R-(+)-Etomoxir

CAS NO.：124083-20-1
Empirical Formula: C17H23ClO4
Molecular Weight: 326.82
MDL number: MFCD11227266
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is R-(+)-Etomoxir?

Chemical properties

Colourless Oil

The Uses of R-(+)-Etomoxir

An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug

What are the applications of Application

R-(+)-Etomoxir is An inhibitor of CPTI (carnitine palmitoyltransferase A (CPT1))

Definition

ChEBI: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester is an aromatic ether.

Biological Activity

etomoxir is a cell-permeable, irreversible, and stereospecific compound. etomoxir is shown to inhibit carnitine palmitoyltransferase (cpt)-1 and dgat activity in the mitochondria of rat heart h9c2 myoblastic cells at a concentration of 1-80 μm and 40 μm, respectively.

Mechanism of action

R-(+)-Etomoxir (ETO) is a carnitine palmitoyltransferase 1 (CPT1) inhibitor. ETO inhibits oxidative phosphorylation (OxPhos), a mitochondrial electron transport chain (ETC) that generates large amounts of ATP in cells. ETO prevents acylcarnitine formation. It is a step necessary for the translocation of fatty acyl chains from the cytoplasmic lysate to the mitochondrial intermembrane space. This step is essential for the production of ATP from fatty acid oxidation.

Properties of R-(+)-Etomoxir

Melting point:	32-34°C
Boiling point:	405.0±25.0 °C(Predicted)
Density	1.163
storage temp.	Inert atmosphere,2-8°C
solubility	≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming
form	Powder
color	Colorless to light yellow
InChI	InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1

Safety information for R-(+)-Etomoxir

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.