R(-)-denopamine
Synonym(s):(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxy-benzyl-alcohol
- CAS NO.：71771-90-9
- Empirical Formula: C18H23NO4
- Molecular Weight: 317.38
- MDL number: MFCD00867122
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:48:07
What is R(-)-denopamine?
Description
Denopamine is a potent orally-active cardiotonic with selective effects on the beta, adrenergic receptors. Unlike isoproterenol or dobutamine, denopamine’s positive inotropic activity is not mediated through the release of catecholamines; its lack of effect on heart rate and myocardial oxygen consumption thus offers significant advantages in the management of congestive heart failure.
Originator
Tanabe Seiyaku (Japan)
The Uses of R(-)-denopamine
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Definition
ChEBI: Denopamine is a dimethoxybenzene.
brand name
Kalgut
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
Properties of R(-)-denopamine
| Melting point: | 135°C |
| Boiling point: | 456.67°C (rough estimate) |
| Density | 1.1949 (rough estimate) |
| refractive index | 1.5740 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: 26 mg/mL, soluble |
| form | powder |
| pka | 9.97±0.26(Predicted) |
| color | white |
Safety information for R(-)-denopamine
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H361:Reproductive toxicity |
| Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for R(-)-denopamine
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