(R)-(+)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
Synonym(s):(R)-4,5-Dihydro-3-hydroxy-2(3H)-furanone
- CAS NO.：56881-90-4
- Empirical Formula: C4H6O3
- Molecular Weight: 102.09
- MDL number: MFCD00211246
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:16:31
What is (R)-(+)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE?
The Uses of (R)-(+)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
(R)-(+)-α-Hydroxy-γ-butyrolactone can be used as a starting material to synthesize:
- δ-Azaproline by reacting with benzyloxycarbonyl aminophthalimide via Mitsunobu reactions.
- Homochiral (R)-2,4-dihydroxybutyramide seco-pseudonucleoside reagents.
- Botryolide B via esterification and ring-closing metathesis reaction.
- Pregnane derivatives containing γ-butyrolactones as potential glucocorticoid agonists.
Properties of (R)-(+)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
| Boiling point: | 133 °C/10 mmHg (lit.) |
| alpha | +66°(23℃, c=1.15, CHCl3) |
| Density | 1.309 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| form | clear liquid |
| pka | 13.07±0.20(Predicted) |
| Specific Gravity | 1.32 |
| color | Colorless to Light yellow |
| optical activity | [α]23/D +66°, c = 1.15 in chloroform |
| BRN | 80588 |
| CAS DataBase Reference | 56881-90-4(CAS DataBase Reference) |
Safety information for (R)-(+)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for (R)-(+)-ALPHA-HYDROXY-GAMMA-BUTYROLACTONE
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