(R)-5-Hydroxymethyldihydrofuran-2-one
Synonym(s):(R)-γ-Hydroxymethyl-γ-butyrolactone;(R)-4,5-Dihydro-5-hydroxymethyl-2(3H)-furanone;(R)-5-Hydroxymethyl-2-oxotetrahydrofuran
- CAS NO.：52813-63-5
- Empirical Formula: C5H8O3
- Molecular Weight: 116.12
- MDL number: MFCD00040528
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:13
What is (R)-5-Hydroxymethyldihydrofuran-2-one?
The Uses of (R)-5-Hydroxymethyldihydrofuran-2-one
Versatile chiral synthon used in the synthesis of natural and unnatural products.
What are the applications of Application
(R)-(?)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a versatile chiral synthon used in the synthesis of natural and unnatural products
Purification Methods
Purify it by column chromatography on Silica gel 60 (Merck 70-230 mesh) and eluting with 7% EtOH/73% CHCl3. IR
Properties of (R)-5-Hydroxymethyldihydrofuran-2-one
| Boiling point: | 101-102 °C0.048 mm Hg(lit.) |
| alpha | -56 º (c=3 in chloroform) |
| Density | 1.238 g/mL at 20 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| pka | 14.12±0.10(Predicted) |
| optical activity | [α]20/D 56°, c = 3 in chloroform |
| BRN | 1680285 |
Safety information for (R)-5-Hydroxymethyldihydrofuran-2-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. |
Computed Descriptors for (R)-5-Hydroxymethyldihydrofuran-2-one
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline (4-Bromophenyl)(3-methoxyphenyl)methanone 4,5,7-Trimethyl-2(1H)-quinolinone 4-(6-HYDROXYHEXYLOXY)BENZOIC ACID 4-Hydroxy-6-methyl-1-(4-methylphenyl)-2naphthalenecarboxylic acid 2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]- NA Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 4 - fluoro- 2 - methoxy- 5 - nitroaniline 1-(2-amino-5-hydroxy phenyl)propan-1-one tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 5-bromo-2-chloro-N- cyclopentylpyrimidin-4- amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3-chlorobenzyl cyanide 3,4 Dimethoxy BenzylcyanideRelated products of tetrahydrofuran
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