2,3-Dihydrobenzofuran
Synonym(s):Coumaran
- CAS NO.：496-16-2
- Empirical Formula: C8H8O
- Molecular Weight: 120.15
- MDL number: MFCD00005855
- EINECS: 207-817-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-11 14:18:34
What is 2,3-Dihydrobenzofuran?
Chemical properties
Colorless to light yellow liqui
The Uses of 2,3-Dihydrobenzofuran
2,3-dihydrobenzofuran is widely used in the synthesis of tricyclic compounds and is also an intermediate raw material for the synthesis of some important drugs. It is used in the synthesis of antitumor agents benzofuran sulfonylureas, HIV protease inhibitor amino acid hydroxyethylenesulfonyl, matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, etc.
Definition
ChEBI: 2,3-dihydrobenzofuran is a member of the class of 1-benzofurans that is the 2,3-dihydroderivative of benzofuran. It has a role as a metabolite.
General Description
Biotransformation of 2,3-dihydrobenzofuran using intact cells of Pseudomonas putida UV4 has been investigated. 2,3-Dihydrobenzofuran is the intermediate formed during catalytic hydrodeoxygenation of benzofuran.
Properties of 2,3-Dihydrobenzofuran
| Melting point: | -21°C |
| Boiling point: | 188-189 °C (lit.) |
| Density | 1.065 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 152 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | alcohol: soluble |
| form | clear liquid |
| color | Colorless to Yellow to Green |
| Specific Gravity | 1.065 |
| Merck | 14,2559 |
| BRN | 111928 |
| CAS DataBase Reference | 496-16-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzofuran, 2,3-dihydro-(496-16-2) |
| EPA Substance Registry System | Coumaran (496-16-2) |
Safety information for 2,3-Dihydrobenzofuran
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 2,3-Dihydrobenzofuran
| InChIKey | HBEDSQVIWPRPAY-UHFFFAOYSA-N |
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